{"id":5620,"date":"2026-09-29T22:43:25","date_gmt":"2026-09-29T22:43:25","guid":{"rendered":"https:\/\/netguide.io\/news\/2026\/09\/29\/le-semaglutide-prolonge-la-duree-de-vie-et-ralentit-le-vieillissement-des-souris-agees\/"},"modified":"2026-09-29T22:43:25","modified_gmt":"2026-09-29T22:43:25","slug":"le-semaglutide-prolonge-la-duree-de-vie-et-ralentit-le-vieillissement-des-souris-agees","status":"publish","type":"post","link":"https:\/\/netguide.io\/news\/fr\/2026\/09\/29\/le-semaglutide-prolonge-la-duree-de-vie-et-ralentit-le-vieillissement-des-souris-agees\/","title":{"rendered":"Le s\u00e9maglutide prolonge la dur\u00e9e de vie et ralentit le vieillissement des souris \u00e2g\u00e9es"},"content":{"rendered":"<div id=\"netgu-3256379268\" class=\"netgu-before-content netgu-entity-placement\"><script async src=\"\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-6258556257245998\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display:block;\" data-ad-client=\"ca-pub-6258556257245998\" \ndata-ad-slot=\"3494115342\" \ndata-ad-format=\"auto\"><\/ins>\n<script> \n(adsbygoogle = window.adsbygoogle || []).push({}); \n<\/script>\n<\/div><p class=\"wp-block-paragraph\"><strong>Le s\u00e9maglutide \u2013 le compos\u00e9 derri\u00e8re les injections de perte de poids comme Ozempic et Wegovy \u2013 prolonge la dur\u00e9e de vie et ralentit les processus de vieillissement du noyau chez les souris \u00e2g\u00e9es. Une \u00e9quipe dirig\u00e9e par Danica Chen \u00e0 l&#8217;Universit\u00e9 de Californie, Berkeley, en collaboration avec le National Institute on Aging (NIA) des \u00c9tats-Unis, a rapport\u00e9 les r\u00e9sultats le 2 septembre 2026 dans la revue <em>Nature<\/em>.<\/strong><\/p>\n<h3 class=\"wp-block-heading\">Ce que l&#8217;\u00e9tude a trouv\u00e9<\/h3>\n<p class=\"wp-block-paragraph\">Les chercheurs ont trait\u00e9 des souris femelles \u00e2g\u00e9es de 20 mois \u2013 \u00e0 peu pr\u00e8s l&#8217;\u00e9quivalent de l&#8217;\u00e2ge adulte avanc\u00e9 chez l&#8217;homme \u2013 avec du s\u00e9maglutide pendant trois mois. M\u00eame apr\u00e8s cette courte fen\u00eatre, les animaux \u00e9taient plus vivants et plus curieux que leurs pairs, avec un meilleur contr\u00f4le du sucre sanguin et une plus grande endurance. Un groupe distinct trait\u00e9 jusqu&#8217;\u00e0 la fin de la vie a atteint une dur\u00e9e de vie m\u00e9diane de pr\u00e8s de 100 jours de plus que les t\u00e9moins non trait\u00e9s.<\/p><div id=\"netgu-3227509828\" class=\"netgu-content netgu-entity-placement\"><aside class=\"deals-top deals-top--compact\">\n\n\t\t\t<h3 class=\"deals-top__title\">Top-Deals<\/h3>\n\t\n\t\t\t<ul class=\"deals-top__list\">\n\t\t\t\t\t\t\t<li class=\"deals-top__item\">\n\t\t\t\t\t<a class=\"deals-top__link\" href=\"https:\/\/netguide.io\/deals\/de\/deals\/moon-knight-digital-watch-face-fuer-wear-os-4\/\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img class=\"deals-top__image\" src=\"https:\/\/netguide.io\/news\/wp-content\/uploads\/sites\/15\/2026\/09\/deal-27-150x150.png\" alt=\"\" width=\"52\" height=\"52\" loading=\"lazy\" \/>\n\t\t\t\t\t\t\n\t\t\t\t\t\t<span class=\"deals-top__body\">\n\t\t\t\t\t\t\t<span class=\"deals-top__name\">MOON KNIGHT Digital Watch Face f\u00fcr Wear OS 4+<\/span>\n\n\t\t\t\t\t\t\t<span class=\"deals-top__meta\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"deals-top__price\">Gratis<\/span>\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<s>0.89 \u20ac<\/s>\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"deals-discount\">-100%<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/span>\n\n\t\t\t\t\t\t<span class=\"deals-top__temperature\">\n\t\t\t\t\t\t\t55\u00b0\n\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t\t<li class=\"deals-top__item\">\n\t\t\t\t\t<a class=\"deals-top__link\" href=\"https:\/\/netguide.io\/deals\/de\/deals\/train-sim-world-7-starter-pack-kostenlos-fuer-ps4-ps5-xbox-pc\/\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img class=\"deals-top__image\" src=\"https:\/\/netguide.io\/news\/wp-content\/uploads\/sites\/15\/2026\/09\/capsule_616x353-11-150x150.jpg\" alt=\"\" width=\"52\" height=\"52\" loading=\"lazy\" \/>\n\t\t\t\t\t\t\n\t\t\t\t\t\t<span class=\"deals-top__body\">\n\t\t\t\t\t\t\t<span class=\"deals-top__name\">Train Sim World 7: Starter Pack kostenlos f\u00fcr PS4, PS5, Xbox, PC<\/span>\n\n\t\t\t\t\t\t\t<span class=\"deals-top__meta\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"deals-top__price\">Gratis<\/span>\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/span>\n\n\t\t\t\t\t\t<span class=\"deals-top__temperature\">\n\t\t\t\t\t\t\t55\u00b0\n\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t\t<li class=\"deals-top__item\">\n\t\t\t\t\t<a class=\"deals-top__link\" href=\"https:\/\/netguide.io\/deals\/de\/deals\/ml2u-watchfaces-fuer-wearos-im-google-play-store-2\/\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img class=\"deals-top__image\" src=\"https:\/\/netguide.io\/news\/wp-content\/uploads\/sites\/15\/2026\/09\/2844734_1-150x150.webp\" alt=\"\" width=\"52\" height=\"52\" loading=\"lazy\" \/>\n\t\t\t\t\t\t\n\t\t\t\t\t\t<span class=\"deals-top__body\">\n\t\t\t\t\t\t\t<span class=\"deals-top__name\">ML2U Watchfaces f\u00fcr WearOS im Google Play Store<\/span>\n\n\t\t\t\t\t\t\t<span class=\"deals-top__meta\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"deals-top__price\">Gratis<\/span>\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<s>1.39 \u20ac<\/s>\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"deals-discount\">-100%<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/span>\n\n\t\t\t\t\t\t<span class=\"deals-top__temperature\">\n\t\t\t\t\t\t\t54\u00b0\n\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t\t<li class=\"deals-top__item\">\n\t\t\t\t\t<a class=\"deals-top__link\" href=\"https:\/\/netguide.io\/deals\/de\/deals\/kostenloses-dlc-bundle-fuer-gears-of-war-e-day-liquid-death-bundle\/\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img class=\"deals-top__image\" src=\"https:\/\/netguide.io\/news\/wp-content\/uploads\/sites\/15\/2026\/09\/2844571_1-150x150.webp\" alt=\"\" width=\"52\" height=\"52\" loading=\"lazy\" \/>\n\t\t\t\t\t\t\n\t\t\t\t\t\t<span class=\"deals-top__body\">\n\t\t\t\t\t\t\t<span class=\"deals-top__name\">Kostenloses DLC-Bundle f\u00fcr Gears of War E-Day \u2013 Liquid Death Bundle<\/span>\n\n\t\t\t\t\t\t\t<span class=\"deals-top__meta\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"deals-top__price\">Gratis<\/span>\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/span>\n\n\t\t\t\t\t\t<span class=\"deals-top__temperature\">\n\t\t\t\t\t\t\t54\u00b0\n\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t\t<li class=\"deals-top__item\">\n\t\t\t\t\t<a class=\"deals-top__link\" href=\"https:\/\/netguide.io\/deals\/de\/deals\/kostenlose-emote-im-clash-royale-store\/\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img class=\"deals-top__image\" src=\"https:\/\/netguide.io\/news\/wp-content\/uploads\/sites\/15\/2026\/09\/share-image-clashroyale-150x150.jpg\" alt=\"\" width=\"52\" height=\"52\" loading=\"lazy\" \/>\n\t\t\t\t\t\t\n\t\t\t\t\t\t<span class=\"deals-top__body\">\n\t\t\t\t\t\t\t<span class=\"deals-top__name\">Kostenlose Emote im Clash Royale-Store<\/span>\n\n\t\t\t\t\t\t\t<span class=\"deals-top__meta\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"deals-top__price\">Gratis<\/span>\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/span>\n\n\t\t\t\t\t\t<span class=\"deals-top__temperature\">\n\t\t\t\t\t\t\t54\u00b0\n\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/li>\n\t\t\t\t\t<\/ul>\n\n\t\t\t\t\t<p class=\"deals-top__more\">\n\t\t\t\t<a href=\"https:\/\/netguide.io\/deals\/\">Alle Deals ansehen \u2192<\/a>\n\t\t\t<\/p>\n\t\t\t<\/aside>\n<\/div>\n<h3 class=\"wp-block-heading\">Plus que la perte de poids<\/h3>\n<p class=\"wp-block-paragraph\">L&#8217;analyse de l&#8217;expression g\u00e9n\u00e9tique a montr\u00e9 que plusieurs caract\u00e9ristiques classiques du vieillissement \u00e9taient att\u00e9nu\u00e9es. Dans certaines r\u00e9gions, l&#8217;effet a m\u00eame d\u00e9pass\u00e9 celui de la restriction des calories avec 24 pour cent moins d&#8217;aliments. Les am\u00e9liorations suivantes ont \u00e9t\u00e9 apport\u00e9es :<\/p>\n<ul class=\"wp-block-list\"><li>marqueurs d&#8217;inflammation inf\u00e9rieurs dans les tissus<\/li><li>une meilleure capacit\u00e9 r\u00e9g\u00e9n\u00e9ratrice des cellules souches dans la moelle osseuse et le cerveau<\/li><li>am\u00e9lioration de la fonction musculaire et m\u00e9moire<\/li><\/ul>\n<h3 class=\"wp-block-heading\">Aucune preuve pour les humains<\/h3>\n<p class=\"wp-block-paragraph\">Les donn\u00e9es proviennent uniquement d&#8217;un mod\u00e8le animal; il faut encore confirmer si l&#8217;effet de prolongation de la dur\u00e9e de vie se r\u00e9percute sur les personnes dans les essais cliniques. Rafael de Cabo, chercheur en NIA, note que de nombreuses maladies chroniques sont profond\u00e9ment enracin\u00e9es dans le processus de vieillissement \u2013 si un m\u00e9dicament BPL-1 le ralentit r\u00e9ellement, un large \u00e9ventail d&#8217;avantages cliniques serait attendu.<\/p>\n<p class=\"wp-block-paragraph\"><em>Sources :<\/em> <a href=\"https:\/\/www.nature.com\/articles\/s41586-026-10940-7\" rel=\"noopener\" target=\"_blank\">Nature (Chen et al., 2026)<\/a> \u00b7 <a href=\"https:\/\/www.nih.gov\/news-events\/news-releases\/glp-1-treatment-late-life-extends-lifespan-animal-model\" rel=\"noopener\" target=\"_blank\">NIH\/NIA<\/a> \u00b7 <a href=\"https:\/\/cen.acs.org\/biological-chemistry\/semaglutide-mouse-longevity\/104\/web\/2026\/09\" rel=\"noopener\" target=\"_blank\">C&#038;EN<\/a><\/p><div id=\"netgu-612236954\" class=\"netgu-after-content netgu-entity-placement\"><script async src=\"\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-6258556257245998\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display:block;\" data-ad-client=\"ca-pub-6258556257245998\" \ndata-ad-slot=\"4559785002\" \ndata-ad-format=\"auto\"><\/ins>\n<script> \n(adsbygoogle = window.adsbygoogle || []).push({}); \n<\/script>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Le s\u00e9maglutide du diab\u00e8te et de la perte de poids a prolong\u00e9 la dur\u00e9e de vie de pr\u00e8s de 100 jours chez les souris femelles \u00e2g\u00e9es et ralenti plusieurs caract\u00e9ristiques du vieillissement, rapporte une nouvelle \u00e9tude Nature de Berkeley.<\/p>\n","protected":false},"author":1,"featured_media":2222,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[],"tags":[],"class_list":["post-5620","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"brizy_media":[],"_links":{"self":[{"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/posts\/5620","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/comments?post=5620"}],"version-history":[{"count":1,"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/posts\/5620\/revisions"}],"predecessor-version":[{"id":5621,"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/posts\/5620\/revisions\/5621"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/media\/2222"}],"wp:attachment":[{"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/media?parent=5620"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/categories?post=5620"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/tags?post=5620"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}