{"id":5104,"date":"2026-09-29T20:34:46","date_gmt":"2026-09-29T20:34:46","guid":{"rendered":"https:\/\/netguide.io\/news\/2026\/09\/29\/la-terapia-de-celulas-car-t-conduce-la-artritis-reumatoide-grave-a-la-remision-en-el-primer-juicio\/"},"modified":"2026-09-29T20:34:46","modified_gmt":"2026-09-29T20:34:46","slug":"la-terapia-de-celulas-car-t-conduce-la-artritis-reumatoide-grave-a-la-remision-en-el-primer-juicio","status":"publish","type":"post","link":"https:\/\/netguide.io\/news\/es\/2026\/09\/29\/la-terapia-de-celulas-car-t-conduce-la-artritis-reumatoide-grave-a-la-remision-en-el-primer-juicio\/","title":{"rendered":"La terapia de c\u00e9lulas CAR-T conduce la artritis reumatoide grave a la remisi\u00f3n en el primer juicio"},"content":{"rendered":"<div id=\"netgu-593179578\" class=\"netgu-before-content netgu-entity-placement\"><script async src=\"\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-6258556257245998\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display:block;\" data-ad-client=\"ca-pub-6258556257245998\" \ndata-ad-slot=\"3494115342\" \ndata-ad-format=\"auto\"><\/ins>\n<script> \n(adsbygoogle = window.adsbygoogle || []).push({}); \n<\/script>\n<\/div><p class=\"wp-block-paragraph\"><strong>Una terapia celular desarrollada primero contra el c\u00e1ncer ha empujado hacia atr\u00e1s la artritis reumatoide severa y resistente al tratamiento en un ensayo cl\u00ednico de primera clase. Un equipo de Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin trat\u00f3 a seis pacientes con una terapia de c\u00e9lulas CAR-T dirigida por CD19. La actividad de la enfermedad cay\u00f3 en todos ellos, y tres pacientes alcanzaron una remisi\u00f3n sostenida sin medicamentos. Los resultados aparecieron a finales de agosto de 2026 en la revista Nature Medicine.<\/strong><\/p>\n<h3 class=\"wp-block-heading\">Reiniciar un sistema inmunitario de mala educaci\u00f3n<\/h3>\n<p class=\"wp-block-paragraph\">En la terapia celular CAR-T, las propias c\u00e9lulas inmunitarias de un paciente est\u00e1n dise\u00f1adas en el laboratorio para reconocer y destruir las c\u00e9lulas B que conducen la enfermedad. En el ensayo, conocido como COMPARE, los seis pacientes, tres mujeres y tres hombres de 31 a 69 a\u00f1os, recibieron una sola infusi\u00f3n del producto mivocabtagene autoleucel despu\u00e9s de que los medicamentos antirheum\u00e1ticos convencionales hubieran fracasado.<\/p><div id=\"netgu-964613404\" class=\"netgu-content netgu-entity-placement\"><aside class=\"deals-top deals-top--compact\">\n\n\t\t\t<h3 class=\"deals-top__title\">Top-Deals<\/h3>\n\t\n\t\t\t<ul class=\"deals-top__list\">\n\t\t\t\t\t\t\t<li class=\"deals-top__item\">\n\t\t\t\t\t<a class=\"deals-top__link\" href=\"https:\/\/netguide.io\/deals\/de\/deals\/moon-knight-digital-watch-face-fuer-wear-os-4\/\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img class=\"deals-top__image\" src=\"https:\/\/netguide.io\/news\/wp-content\/uploads\/sites\/15\/2026\/09\/deal-27-150x150.png\" alt=\"\" width=\"52\" height=\"52\" loading=\"lazy\" \/>\n\t\t\t\t\t\t\n\t\t\t\t\t\t<span class=\"deals-top__body\">\n\t\t\t\t\t\t\t<span 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src=\"https:\/\/netguide.io\/news\/wp-content\/uploads\/sites\/15\/2026\/09\/2844571_1-150x150.webp\" alt=\"\" width=\"52\" height=\"52\" loading=\"lazy\" \/>\n\t\t\t\t\t\t\n\t\t\t\t\t\t<span class=\"deals-top__body\">\n\t\t\t\t\t\t\t<span class=\"deals-top__name\">Kostenloses DLC-Bundle f\u00fcr Gears of War E-Day \u2013 Liquid Death Bundle<\/span>\n\n\t\t\t\t\t\t\t<span class=\"deals-top__meta\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"deals-top__price\">Gratis<\/span>\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/span>\n\n\t\t\t\t\t\t<span class=\"deals-top__temperature\">\n\t\t\t\t\t\t\t54\u00b0\n\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t\t<li class=\"deals-top__item\">\n\t\t\t\t\t<a class=\"deals-top__link\" href=\"https:\/\/netguide.io\/deals\/de\/deals\/kostenlose-emote-im-clash-royale-store\/\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img class=\"deals-top__image\" src=\"https:\/\/netguide.io\/news\/wp-content\/uploads\/sites\/15\/2026\/09\/share-image-clashroyale-150x150.jpg\" alt=\"\" width=\"52\" height=\"52\" loading=\"lazy\" \/>\n\t\t\t\t\t\t\n\t\t\t\t\t\t<span class=\"deals-top__body\">\n\t\t\t\t\t\t\t<span class=\"deals-top__name\">Kostenlose Emote im Clash Royale-Store<\/span>\n\n\t\t\t\t\t\t\t<span class=\"deals-top__meta\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"deals-top__price\">Gratis<\/span>\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/span>\n\n\t\t\t\t\t\t<span class=\"deals-top__temperature\">\n\t\t\t\t\t\t\t54\u00b0\n\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/li>\n\t\t\t\t\t<\/ul>\n\n\t\t\t\t\t<p class=\"deals-top__more\">\n\t\t\t\t<a href=\"https:\/\/netguide.io\/deals\/\">Alle Deals ansehen \u2192<\/a>\n\t\t\t<\/p>\n\t\t\t<\/aside>\n<\/div>\n<p class=\"wp-block-paragraph\">Despu\u00e9s del tratamiento, los niveles de autoanticuerpo cayeron agudamente y los foci inflamatorios en las articulaciones ya no eran detectables. Investigadores principales David Simon y Gerhard Kr\u00f6nke describen el efecto como un &#8220;reset&#8221; espec\u00edfico de la parte del sistema inmunitario que alimenta la inflamaci\u00f3n.<\/p>\n<h3 class=\"wp-block-heading\">Peque\u00f1a muestra, etapa temprana<\/h3>\n<p class=\"wp-block-paragraph\">A pesar de los datos alentadores, los investigadores piden precauci\u00f3n. Este es el primer ensayo mundial de su tipo, con s\u00f3lo seis pacientes. Las respuestas variaron, y en una persona la enfermedad regres\u00f3 despu\u00e9s de una remisi\u00f3n inicial. En esta etapa temprana, no se puede reclamar una cura. Se planea un estudio comparativo m\u00e1s amplio con diez pacientes m\u00e1s.<\/p>\n<p class=\"wp-block-paragraph\">Fuentes: <a href=\"https:\/\/www.nature.com\/articles\/s41591-026-04603-3\" rel=\"noopener\" target=\"_blank\">Nature Medicine<\/a>, <a href=\"https:\/\/www.sciencedaily.com\/releases\/2026\/08\/260828082330.htm\" rel=\"noopener\" target=\"_blank\">ScienceDaily<\/a>, <a href=\"https:\/\/www.genengnews.com\/topics\/translational-medicine\/car-t-cell-therapy-puts-severe-rheumatoid-arthritis-into-remission-in-first-clinical-trial\/\" rel=\"noopener\" target=\"_blank\">GEN<\/a><\/p><div id=\"netgu-2636005346\" class=\"netgu-after-content netgu-entity-placement\"><script async src=\"\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-6258556257245998\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display:block;\" data-ad-client=\"ca-pub-6258556257245998\" \ndata-ad-slot=\"4559785002\" \ndata-ad-format=\"auto\"><\/ins>\n<script> \n(adsbygoogle = window.adsbygoogle || []).push({}); \n<\/script>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>En la Charit\u00e9 de Berl\u00edn, una terapia celular CAR-T redujo agudamente la actividad de la enfermedad en seis personas con artritis reumatoide severa; tres alcanzaron la remisi\u00f3n libre de drogas.<\/p>\n","protected":false},"author":1,"featured_media":2222,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[],"tags":[],"class_list":["post-5104","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"brizy_media":[],"_links":{"self":[{"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/posts\/5104","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/comments?post=5104"}],"version-history":[{"count":1,"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/posts\/5104\/revisions"}],"predecessor-version":[{"id":5105,"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/posts\/5104\/revisions\/5105"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/media\/2222"}],"wp:attachment":[{"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/media?parent=5104"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/categories?post=5104"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/tags?post=5104"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}