{"id":2223,"date":"2026-08-31T04:30:00","date_gmt":"2026-08-31T04:30:00","guid":{"rendered":"https:\/\/netguide.io\/news\/?p=2223"},"modified":"2026-08-31T04:30:00","modified_gmt":"2026-08-31T04:30:00","slug":"car-t-zelltherapie-rheumatoide-arthritis-studie","status":"publish","type":"post","link":"https:\/\/netguide.io\/news\/de\/2026\/08\/31\/car-t-zelltherapie-rheumatoide-arthritis-studie\/","title":{"rendered":"CAR-T-Zelltherapie: Schwere rheumatoide Arthritis in erster klinischer Studie zur\u00fcckgedr\u00e4ngt"},"content":{"rendered":"<div id=\"netgu-4017096142\" class=\"netgu-before-content netgu-entity-placement\"><script async src=\"\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-6258556257245998\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display:block;\" data-ad-client=\"ca-pub-6258556257245998\" \ndata-ad-slot=\"3494115342\" \ndata-ad-format=\"auto\"><\/ins>\n<script> \n(adsbygoogle = window.adsbygoogle || []).push({}); \n<\/script>\n<\/div><p class=\"wp-block-paragraph\"><strong>Eine urspr\u00fcnglich gegen Krebs entwickelte Zelltherapie hat in einer ersten klinischen Studie schwere, therapieresistente rheumatoide Arthritis deutlich zur\u00fcckgedr\u00e4ngt. Ein Team der Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin behandelte sechs Betroffene mit einer CD19-gerichteten CAR-T-Zelltherapie. Bei allen sank die Krankheitsaktivit\u00e4t, drei Patientinnen und Patienten erreichten eine anhaltende, medikamentenfreie Remission. Die Ergebnisse erschienen Ende August 2026 im Fachjournal Nature Medicine.<\/strong><\/p>\n<h3 class=\"wp-block-heading\">Immunsystem wird gezielt neu justiert<\/h3>\n<p class=\"wp-block-paragraph\">Bei der CAR-T-Zelltherapie werden k\u00f6rpereigene Immunzellen im Labor so ver\u00e4ndert, dass sie krankheitstreibende B-Zellen erkennen und zerst\u00f6ren. In der als COMPARE bezeichneten Studie erhielten die sechs Erkrankten \u2013 drei Frauen und drei M\u00e4nner im Alter von 31 bis 69 Jahren \u2013 eine einmalige Infusion des Pr\u00e4parats Mivocabtagen-Autoleucel, nachdem herk\u00f6mmliche Antirheumatika versagt hatten.<\/p>\n<p class=\"wp-block-paragraph\">Nach der Behandlung sanken die Autoantik\u00f6rper-Werte stark, entz\u00fcndliche Herde in den Gelenken waren nicht mehr nachweisbar. Bemerkenswert: Auch als sich die B-Zellen sp\u00e4ter wieder aufbauten, kehrte die Entz\u00fcndung bei den meisten nicht zur\u00fcck. Die Studienleiter David Simon und Gerhard Kr\u00f6nke sprechen von einem gezielten &#8220;Neustart&#8221; jenes Teils des Immunsystems, der die Erkrankung antreibt.<\/p>\n<h3 class=\"wp-block-heading\">Kleine Fallzahl, fr\u00fche Phase<\/h3>\n<p class=\"wp-block-paragraph\">Trotz der ermutigenden Daten mahnen die Forschenden zur Vorsicht: Es handelt sich um die weltweit erste Studie dieser Art mit nur sechs Behandelten. Die Verl\u00e4ufe waren unterschiedlich, bei einer Person kehrte die Erkrankung nach anf\u00e4nglicher Remission zur\u00fcck. Aussagen \u00fcber eine Heilung l\u00e4sst die fr\u00fche Phase nicht zu. Eine gr\u00f6\u00dfere Vergleichsstudie mit weiteren zehn Betroffenen ist geplant.<\/p>\n<p class=\"wp-block-paragraph\">Quellen: <a href=\"https:\/\/www.nature.com\/articles\/s41591-026-04603-3\" target=\"_blank\" rel=\"noopener\">Nature Medicine<\/a>, <a href=\"https:\/\/www.sciencedaily.com\/releases\/2026\/08\/260828082330.htm\" target=\"_blank\" rel=\"noopener\">ScienceDaily<\/a>, <a href=\"https:\/\/www.genengnews.com\/topics\/translational-medicine\/car-t-cell-therapy-puts-severe-rheumatoid-arthritis-into-remission-in-first-clinical-trial\/\" target=\"_blank\" rel=\"noopener\">GEN<\/a><\/p><div id=\"netgu-2067945870\" class=\"netgu-after-content netgu-entity-placement\"><script async src=\"\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-6258556257245998\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display:block;\" data-ad-client=\"ca-pub-6258556257245998\" \ndata-ad-slot=\"4559785002\" \ndata-ad-format=\"auto\"><\/ins>\n<script> \n(adsbygoogle = window.adsbygoogle || []).push({}); \n<\/script>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>CAR-T-Zelltherapie senkte an der Charit\u00e9 Berlin bei sechs Patienten mit schwerer rheumatoider Arthritis die Krankheitsaktivit\u00e4t \u2013 drei ohne Medikamente in Remission.<\/p>\n","protected":false},"author":1,"featured_media":2222,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[],"tags":[],"class_list":["post-2223","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"brizy_media":[],"_links":{"self":[{"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/posts\/2223","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/comments?post=2223"}],"version-history":[{"count":1,"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/posts\/2223\/revisions"}],"predecessor-version":[{"id":2231,"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/posts\/2223\/revisions\/2231"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/media\/2222"}],"wp:attachment":[{"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/media?parent=2223"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/categories?post=2223"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/netguide.io\/news\/wp-json\/wp\/v2\/tags?post=2223"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}